Could Raman Spectroscopy Distinguish Between P. falciparum and P. vivax Infection?

The erythrocytes obtained from patients diagnosed with Plasmodium falciparum or vivax infection (two groups of five each) and treated in the Department Infectious Diseases, University Hospital Kraków, were measured using Raman spectroscopy method (1–2 cells each patient) then compared results these during their convalescence. Principal Component Analysis (PCA) was used to determine variance between spectra. Changes heme structure observed by v4 oxidation state marker other hemozoin bands, as well protein side chains bands. recognized bands allow differentiate changes taking place red blood development vivax. 1385 cm?1 Asp band along 1587 Gln vibrations at beginning hospitalization specify invasion P. that occurs basigin receptor which requires respective glycosylation. 1361 1544 Trp indicate stage parasite, formation ligand-receptor complex. To our knowledge, this is first spectroscopic observation we can distinguish species.